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Sildenafil is often a strong and selective inhibitor of cGMP distinct phosphodiesterase sort 5 (PDE5) while in the corpus cavernosum, where by PDE5 is accountable for degradation of cGMP. Sildenafil contains a peripheral web page of motion on erections. Sildenafil has no direct relaxant effect on isolated human corpus cavernosum but potently enhanc